Fig. 1
From: CAR-NKT cell therapy: a new promising paradigm of cancer immunotherapy
A.The various generations of CAR structure. The base structure comprises the ectodomain, transmembrane domain, and CD3ζ, which are shared among all generations. The main differences are related to the co-stimulatory domain and the related signaling cascades. Changes in each part of the structure can create new CARs with different features. B.The function ofarmored NKT cell with CAR-structure. The NKT cell can utilize CAR-based recognition, innate activatory receptor-based recognition, and the relevance of the “double-function” for better anti-cancer cytotoxicity.