Fig. 2
From: CAR-NKT cell therapy: a new promising paradigm of cancer immunotherapy
The different interactions of CAR-NKT cells with other immune cells and tumor cells. The CAR-NKT cell, by various methods, can regulate the immune system and lytic the tumors by or not CAR. Also, CAR-NKT cell can activate other immune cells like CD8-, CD4-, and NK-cells, and macrophages-. For instance, CAR-NKT cells can change the immune suppressive macrophages into immune-stimulating macrophages, and by increasing perforin and granzyme B, improve tumor eradication.