Fig. 10

Analysis of tumor mutation burden (TMB). A-C Distribution of the dysfunction scores (A), exclusion scores (B), and TIDE scores (C) between the two groups. D Prediction of the response to anti-PD1 and anti-CTLA4 immunotherapy in the high- and low-risk groups by the submap algorithm. E–F Waterfall plots of mutation characteristics in the two groups. G Differences of TMB between the two groups. H K-M survival curve of the OS between the high- and low-TMB groups. I Kaplan–Meier survival curve of the OS stratified by both TMB and risk score. *P < 0.05, **P < 0.01, ***P < 0.001, ns: no significance