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Fig. 3 | Cancer Cell International

Fig. 3

From: Local radiotherapy for murine breast cancer increases risk of metastasis by promoting the recruitment of M-MDSCs in lung

Fig. 3

Exosomes released from X-ray-irradiated 4T1 cells promote migration of MDSCs. a, b Morphology and chrematistic identification of exosomes. a Morphology and size of exosomes were observed by electron microscopy, b Western blot. c 20 Gy X-ray enhanced exosomes release (The results were repeated three times). dIn vitro chemotaxis assay of MDSCs towards exosomes derived from 4T1 cells or X-ray irradiated 4T1 cells. Treatment with CXCR2 inhibitor SB225002 or CCR2 inhibitor RS504393 to inhibit CXCR2 or CCR2 signal was performed in MDSCs. Results are expressed as percentage of control (PBS) ± SEM. *p < 0.05, **p < 0.001 vs. PBS; $ p < 0.05, $$p < 0.01 vs. ir/4T1-exo

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Cancer Cell International

ISSN: 1475-2867

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