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Fig. 4 | Cancer Cell International

Fig. 4

From: Local radiotherapy for murine breast cancer increases risk of metastasis by promoting the recruitment of M-MDSCs in lung

Fig. 4

Irradiated 4T1-derived exosomes (ir/4T1-exo) promoted the recruitment of M-MDSCs and colonization circulating 4T1 cells in normal mouse lungs. a-c Normal BALB/c mice were injected exosomes (4T1-exo or ir/4T1-exo) every other day for 3 weeks, M-MDSC or PMN-MDSCs frequency was analyzed by FCM (*p < 0.05, **p < 0.01). The representative flow cytometry data was shown. d On the second day after exosome injection, 5x104/mouse 4T1 cells were inoculated via tail vein. Representative images of lung metastatic nodules were shown. Images are shown at 4 x magnification. Tumor sections from all 18 mice/group were examined

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Cancer Cell International

ISSN: 1475-2867

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