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Fig. 1 | Cancer Cell International

Fig. 1

From: Gastric cancer cell-originated small extracellular vesicle induces metabolic reprogramming of BM-MSCs through ERK-PPARγ-CPT1A signaling to potentiate lymphatic metastasis

Fig. 1

The ability of LNM-GC-sEV to educate BM-MSCs is determined by lymphatic metastatic capacities of GC cells themselves. A-G Comparison of the ability of AGS-sEV, HGC-27-sEV and HGC-27L-sEV to educate BM-MSCs in vitro. A α-SMA expression in BM-MSCs treated with different GC-sEV was measured by immunofluorescence staining (scale bars, 100 μm). B, C Morphology and quantitative analysis of tubule formation (scale bar, 200 μm). D-G Morphology and count of migrated and invaded cells (scale bar, 100 μm). H-J The tumor-promoting capacity of the above treated BM-MSCs was evaluated in vivo. H The harvested popliteal LNs. I Weight of popliteal LNs. J Representative images of pan-cytokeratin (AE1/AE3) staining in the popliteal LNs. (Top: scale bars, 100 μm; Bottom: scale bars, 20 μm). *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001

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Cancer Cell International

ISSN: 1475-2867

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