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Fig. 5 | Cancer Cell International

Fig. 5

From: Gastric cancer cell-originated small extracellular vesicle induces metabolic reprogramming of BM-MSCs through ERK-PPARγ-CPT1A signaling to potentiate lymphatic metastasis

Fig. 5

ERK/PPARγ/CPT1A signaling mediates sEV-CD44 facilitating BM-MSC FAO. A–C Western blotting analysis of P-ERK, ERK, PPARγ and CPT1A in BM-MSCs treated with GC-sEV, CD44-sEV and si-CD44-sEV. D Analysis of the effect of U0126 on PPARγ and CPT1A expression using Western blotting. E–G Analysis of the effect of U0126 on CPT1 activity, β-oxidation rate and ATP level in BM-MSCs. H Western blotting analysis of the effect of GW9662 on CPT1A protein expression. I–K The effect of GW9662 on CPT1 activity, β-oxidation rate, ATP level in BM-MSCs were analyzed. L α-SMA staining by immunofluorescence. M Tubule formation assay. N, O Migration and invasion analysis by transwell. **P < 0.01; ***P < 0.001; ****P < 0.0001

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Cancer Cell International

ISSN: 1475-2867

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