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Fig. 7 | Cancer Cell International

Fig. 7

From: Gastric cancer cell-originated small extracellular vesicle induces metabolic reprogramming of BM-MSCs through ERK-PPARγ-CPT1A signaling to potentiate lymphatic metastasis

Fig. 7

Increased expression of CD44, CPT1A, CXCL8 and STC1 in GC tissues, serum and stroma are associated with poor prognosis of GC patients and LNM. A The expression of ENG, THY1, NT5E, CD44, CPT1A, IL-8 and STC1 in TCGA GC tumor and GTEx normal stomach tissues. B Diagnostic value of CD44, CPT1A, IL-8 and STC1 for GC. C–F Kaplan–Meier analysis of IL-8 and STC1 association with OS of MSC enriched and decreased GC patients. G Forest plot of specific molecules effect on OS of GC patients. H–J Comparison of serum CD44, IL-8 and STC1 concentration between healthy people and GC patients. K Diagnostic value of serum CD44 and STC1 for GC. L–N The mRNA levels of IL-8 and STC1 in BM-MSCs and GC-MSCs were detected by RT-qPCR. O Correlation of CPT1A with IL-8 and STC1 in MSCs. P–S IHC staining analysis of primary tumor sites in GC patients with or without LNM. P, Q Representative images. R IHC staining scores of CD44, CPT1A, IL-8, and STC1 in GC stroma (n = 5 samples for each group). S Correlation of CPT1A with IL-8 and STC1 in CD105 positive stromal cells. Data are shown as the mean ± SEM. Non-significant (ns) P > 0.05; *P < 0.05; **P < 0.01; ***P < 0.001

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Cancer Cell International

ISSN: 1475-2867

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