Fig. 6From: Pien-Tze-Huang prevents hepatocellular carcinoma by inducing ferroptosis via inhibiting SLC7A11-GSH-GPX4 axisPZH may promote ferroptosis in HCC cells by inhibiting SLC7A11-GSH-GPX4 axis (by Figdraw). In HCC cells, by inhibiting SLC7A11, PZH leads to decreased cystine uptake and reduced GSH synthesis, which in turn downregulates GPX4, leading to cellular/subcellular membrane damage caused by the accumulation of iron-dependent lipid peroxidesBack to article page