Fig. 2
Expression pattern of inhibitory receptors during CAR T manufacturing process. CAR T cell population positive for TIM3 (A), PD1 (B), and A2aR (C) in EOC patient-derived T cells during CAR T cell manufacturing steps. The frequency of Tpex(D) and Ttex(E) cells during manufacturing steps of CAR T cells derived from EOC patient T cells. Median fluorescence intensity (MFI) of A2aR (F), TIM3 (G), and PD1 (H) in EOC patient-derived T cells during CAR T cells manufacturing process. Healthy donors (n = 30) and EOC patients (n = 30) data were analyzed using RM one-way ANOVA and Tukey multiple comparison test. *P < 0.05; **P < 0.01; ***P < 0.001. Data are presented as mean ± SD.