Fig. 5
Effect of CarboTaxol treatment on T cell expansion, frequency, and expression pattern of immune inhibitory receptors during CAR T cell manufacturing process. Fold increase of T cells from CarboTaxol-treated and untreated patients post T cell activation (A). CD3 expression after T cell activation in CarboTaxol treated and newly diagnosed patients (B). The percentage of A2aR (C), TIM3 (D), PD1 (E) positive cells, and the frequency of Ttex(F) and Tpex cells (G) during CAR T cell manufacturing process in CarboTaxol-treated and newly diagnosed patients. Data from CarboTaxol-treated patients (n = 20) and new patients (n = 10) were analyzed using Welch’s t-test. *P < 0.05; **P < 0.01; ***P < 0.001. Data are presented by mean ± SD.