Fig. 3
From: Melatonin blunted the angiogenic activity in 3D colon cancer tumoroids by the reduction of endocan
Hematoxylin-Eosin staining. In control tumoroids, dense parenchyma is evident with dividing (red arrow) and necrotic cells (black arrows). In melatonin-treated tumoroids, the number of necrotic cells increased. In groups treated with 4 mM melatonin, small-sized cell aggregates with prominent necrotic changes can be detected. Based on the data, 10 mM melatonin efficiently disaggregated cells within the tumoroids parenchyma with numerous necrotic changes