Table 4 Current status of transplantation based on multiple interfering factors in different tumors

Cholangiocarcinoma

NOD/SCID

Surgical resection

–

4 × 4 mm

s.c.^*

5.8

[93]

BRJ

Surgical resection

ICC, ECC

8–27 mm³

s.c

75

[40]

Breast cancer

Nude

Surgical resection

ER + 

2–3 × 2–3 mm

fat pad^**

2.5

[94]

ER − 

24.3

SCID/Beige

Biopsies

ER + 

1 mm³

s.c

19

[68]

NSG

ER − 

31.3

NOD

–

Primary tumors

5 mm³

s.c

100

[95]

Metastasis model

1 × 10⁶ Cell suspensions

fat pad (orthotopically injected (tail vein)

57

NOD-SCID /NSG

Surgical resection

–

8 mm³

s.c

27.4

[45]

Pancreatic cancer

SCID

Surgical resection

Pancreatic ductal adenocarcinomas

2–3 mm

s.c

67

[96]

NSG

1–3 mm³

71.1

[97]

Nude

0.5 mm³

44.8

[98]

Gastric cancer

BALB/C

Surgical resection

–

–

s.c

28.1

[99]

NOD/SCID

Biopsies

2 × 2 × 2 mm³

34.1

[88]

Nude/SCID

Surgical resection

2 mm³

16.9/26.9

[100]

Nude/NOG

Surgical resection

3 × 3 × 3 mm³

24.2

[17]

Nude

Surgical resection

3 × 3 × 3 mm³

94

[101]

Colorectal cancer

NMRI/NOG

Surgical resection

–

Smaller fragments

s.c

60

[102]

Nude/NSG

Surgical resection

–

52

[103]

NSG

–

2–3 mm³

100

[104]

NSG

Surgical resection

 < 150 μm (50% Matrigel)

89.9

[105]

Lung cancer

NOD/SCID

Surgical resection/Biopsies

NSCLC

2–3 mm³

s.c

35

[79]

NSG

Surgical resection

NSCLC

2 mm (10% Matrigel)

s.c

29

[106]

Nude

Surgical resection

NSCLC

25–30 mm³

s.c

30–40

[107]

NOD/SCID

Surgical resection

NSCLC

r.c

90

NSG

EBUS-TBNA

NSCLC

1.0 × 10⁵ Cell suspensions (10% Matrigel)

s.c

42.1

[108]

NSG

SCLC

s.c

67

Ovarian cancer

Nude

–

–

–

s.c

19.8

[109]

BALB/C

Surgical resection

EOC

 < 2–3 mm

r.c.^***

48.8

[110]

SCID

Surgical resection

–

0.3–0.5 cm³ tumor slurry (50% McCoy's media)

s.c

74

[111]

NSG

Surgical resection

HG-SOC

1–3 mm³/ < 1 mm³

s.c./intra-ovarian bursal

83

[112]

NSG

–

–

–

i.p.^****

31

[113]

BALB/SCID

Surgical resection

EOC/NOC

–/3 mm³

s.c./ovarian in situ (OIS)

18.52

[114]

Head and neck cancer

Nude/NOG

Surgical resection/Biopsies

HNSCC

3 × 3 × 3 mm³

s.c

24.2

[115]

NSG

Surgical resection

HPV + HNSCC

–

s.c

64

[116]

Glioblastoma

NSG

Surgical resection

MB, ATRT, HGG, EPN

10⁵ Cell suspensions

orthotopic

30

[117]

Prostate cancer

Nude

rPE

–

2 × 2 × 1 mm

r.c

39

[118]

NOD/SCID

1 × 2 × 1 mm

orthotopic

48

NSG/NOG

rPE/TUR-P

–

4–5 mm/2–3 mm (testosterone)

s.c./r.c

37

[70]

SCID

TAN

LuCaP

3–4 mm

s.c

10

[119]

Melanoma

NOG

Biopsies

Stage III and IV metastatic

Cell suspensions (50% Matrigel)

s.c

88.4

[120]

NSG

Biopsies

–

Fragments (100 μL Matrigel)

s.c

65.8

[5]

Renal cell carcinoma

Nude

Surgical resection

–

5 mm³

s.c./orthotopic

8.9

[121]

NOD/SCID

Surgical resection

–

2–3 mm

r.c

37.2

[77]

NSG

Biopsies

–

8- 27 mm³/1–6 × 10⁶ cells (50% Matrigel)

s.c

45

[122]

Nude

Surgical resection

Nephroblastoma

1 × 3 × 3 mm³

r.c

67

[123]

Medulloblastoma

SCID

Surgical resection

SFRP, WIF1, NPR3, KCNA

Tumor cells (1 × 10⁵)

orthotopic

52

[124]

Cervical Cancer

NOD/SCID

Biopsies

Cancer, dysplasia, and normal cervical tissues

1 mm³

r.c

71.4

[125]

Malignant Pleural Mesothelioma

NOD/SCID

Extrapleural pneumonectomy, decortication, or biopsy

–

1 mm³

s.c

40

[126]