MFI2 upregulation promotes malignant progression through EGF/FAK signaling in oral cavity squamous cell carcinoma

Table 1 List of 37 differentially expressed genes in OSCC via comparison of the OSCC-OncoScan and OSCC-TCGA-DEG datasets

Gene name	CNV in OncoScan	T/N in OSCC-TCGA	Dysregulated in HNSCC (ref.)	p value^a of OS rate in OSCC-TCGA
CSMD1	Del	0.10	Yes [45]
DOCK3	Del	0.32		0.14
FHIT	Del	0.14	Yes [46]
KAT2B	Del	0.31		0.58
LPL	Del	0.30	Yes [47]
MITF	Del	0.29	Yes [48]
NAT2	Del	0.06	Yes [49]
PPARG	Del	0.11		0.21
ROBO2	Del	0.06	Yes [50]
SCARA5	Del	0.18		0.098
SLC7A2	Del	0.20		0.79
THRB	Del	0.44	Yes [51]
ATP6V1C1	Amp	2.03	Yes [52]
CSMD3	Amp	66.29	Yes [53]
E2F1	Amp	3.57	Yes [54]
EIF5A2	Amp	3.41	Yes [55]
EXT1	Amp	3.20	Yes [56]
FANCC	Amp	2.06	Yes [57]
FANCG	Amp	2.14	Yes [58]
GLI3	Amp	2.08		0.78
HECW1	Amp	2.36		0.48
HIF1A	Amp	2.02	Yes [59]
IGFBP1	Amp	78.17	Yes [60]
IGFBP3	Amp	3.03	Yes [61]
INHBA	Amp	28.45	Yes [62]
LEPREL1	Amp	4.54		0.32
MFI2	Amp	2.64		0.021^b
PAX5	Amp	11.83	Yes [63]
PCNA	Amp	2.06	Yes [64]
PLEC	Amp	2.18	Yes [65]
PRKDC	Amp	2.00	Yes [66]
RCOR2	Amp	2.59		0.23
RECQL4	Amp	3.26	Yes [67]
ROR2	Amp	3.46	Yes [68]
SOX12	Amp	2.34		0.10
TFRC	Amp	2.27	Yes [69]
TP63	Amp	2.53	Yes [70]

Amp., amplification; CNV, copy number variation; Del., deletion; T/N, tumor tissue sample and normal tissue sample; TCGA, The Cancer Genome Atlas; HNSCC, Head and neck squamous cell carcinoma
^ap value is determined by the log-rank tests
^bThese are considered statistically significant

ISSN: 1475-2867