Table 1 The effects of flavonoids on metastatic molecules

Pancreas

MMP9, NFκB

-

-

[46]

Melanoma

βcatenin, WNT, DVL

-

-

[118]

Fisetin

Colon

-

NFκB, βcatenin

-

[119]

Blood

-

NFκB, IKK

-

[120]

Larynge

-

NFκB

-

[47]

Fisetin + erlotinib

Lung

SNAIL

-

E-cadherin

[121]

Fistein + paclitaxel

Lung

SNAIL2, TWIST, MMP2

-

-

[122]

Breast

VEGF, MMP9

JAK1, STAT3, TWIST

-

[123,124,125,126]

Blood

βcatenin

-

-

[127]

Quercetin

Human teratocarcinoma

-

βcatenin

-

[128]

Lung

-

SNAIL1/2, TWIST, N-cadherin

E-cadherin

[129]

Hela

NFκB

-

IKb

[130]

Colon

-

βcatenin

-

[131]

Prostate

-

NFκB

IKb

[132]

Breast

VEGF, MMP9

JAK1, JAK2, STAT3

-

[58, 133]

Apigenin

Lung

MMP2, MMP9, GSK3β

SNAIL1/2, N-cadherin

-

[134, 135]

Colorectal

AXIN, βcatenin

βcatenin

-

[135, 136]

Osteosarcoma

βcatenin

-

-

[59]

Prostate

MMP9

-

-

[137]

Pancreas

MMP2, MMP7, MMP9, STAT3

STAT3

-

[138]

Luteolin

Glioblastoma

MMP2, MMP9

N-cadherin, βcatenin

E-cadherin

[139]

Breast

SNAIL1/2, N-cadherin, βcatenin

-

E-cadherin

[64]

Colorectal

MMP9

-

-

[65]

Silibinin

Bladder

-

GSK3β, βcatenin

-

[56]

Silibinin

Kidney

MMP9

MMP9

-

[140]

Curcumin

Glioblastoma

-

NFκB

-

[141]

Curcumin

Melanoma

-

NFκB, IKK

-

[142]

Butein

Liver

MMP9

MMP9

-

[143]

Butein

Prostate

IKK

NFκB

IKb

[62]

Chalcone

Colon

-

STAT3

-

[63]

Resveratrol

Colorectal

-

NFκB, MMP9, MMP13

-

[144]

Ginger + Gelam honey

Colon

βcatenin, GSK3β

-

-

[145]

Epigallocatechin-3-gallate

Prostate

-

NFκB

-

[146]

Baicalein

Breast

GSK3β

GSK3β

-

[147]

Cardamonin

Breast

GSK3β, VEGF

βcatenin

-

[148]