Fig. 1

AGTR1 was overexpressed in GBM and correlated with poor survival in glioma patients. A, B Kaplan‒Meier survival analysis based on AGTR1 expression in the CGGA and TCGA datasets created using the CGGA and GEPIA platforms, respectively. C AGTR1 mRNA expression in grade I to grade IV glioma is presented as a scatter plot of data obtained from the GENT2 database. Statistical analysis was performed with Student's t test (***p < 0.001 compared to the grade IV glioma group). D Expression of AGTR1 mRNA in normal brain, U87MG, LN229, GBM8401, U118MG, and LNZ308 glioma cell lines. Gene expression was normalized to that in the normal brain (*p < 0.05, **p < 0.01, and ***p < 0.001 compared to the normal brain tissue group). These data support that upregulated AGTR1 is associated with a poor survival outcome in GBM patients and with the progression of GBM