Fig. 8

Telmisartan inhibits tumor sphere formation and has an anti-GBM effect in vivo. A, B Representative images of tumor spheres formed from 2 GBM patient specimens. Scale bar, 100 μm. The cells treated with the indicated dosage of telmisartan were cultured in 6-well plates for 14 days. Data are shown as the mean ± SEM. of at least four independent tests; **p < 0.01. C Treatment protocol for the C6 glioma orthotopic mouse model. D Representative MR images of mice on D3, D7, D10, and D14 after glioma cell implantation. E Time evolution of tumor volume on D3, D7, D10, and D14 after initial tumor inoculation and presented as SEM. n = 4 for each group. *P < 0.05. These data showed telmisartan inhibits tumor sphere formation and has an anti-GBM effect in vivo.