Table 8 Project Hope Prediction Analysis
Residues | Hydrophobicity | Domain | Size | Charge | Conservation site | Amino acid Properties |
|---|---|---|---|---|---|---|
C52S | Wild > Mutant | C1A | - | - | Highly Conserved | Perturbed folding; Loss of Hydrophobic interactions |
C114Y | Wild > Mutant | C1B | Wild < Mutant | - | Highly Conserved | Bumps/repulsions of ligands; Loss of Hydrophobic interactions; Disrupted folding |
D115Y | Wild < Mutant | C1B | Wild < Mutant | Wild-Negative, Mutant-Neutral | Highly Conserved | Loss of hydrogen bonds; Disrupted correct folding; Bumps/repulsions of ligands |
G128R | Wild > Mutant | C1B | Wild < Mutant | Wild- Neutral, Mutant-Positive | Highly Conserved | Bumps/repulsions of ligands; Disrupted folding interactions |
C131Y | Wild > Mutant | C1B | Wild < Mutant | - | Highly Conserved | Bumps/repulsions of ligands; Disrupted folding interactions; Loss of Hydrophobic interactions |
V138M | - | C1B | Wild < Mutant | - | Highly Conserved | Bumps/repulsions of ligands; Disrupted folding interactions |
C150R | Wild > Mutant | C1B | Wild < Mutant | Wild-Neutral,Mutant-Positive | Highly Conserved | Bumps/repulsions of ligands; Disrupted folding interactions; Loss of Hydrophobic interactions |
G159R | Wild > Mutant | Between C1B and C2 | Wild < Mutant | Wild-Neutral Mutant-Positive | Highly Conserved | Bumps/repulsions of ligands; Disrupted folding interactions |
G360S | - | C3/C4 | Wild < Mutant | - | Highly Conserved | Bumps/repulsions of ligands; Disrupted folding interactions |
L403P | - | C3/C4 | Wild > Mutant | - | Highly Conserved | Bumps/repulsions of ligands; Disrupted folding interactions |
L468P | - | C3/C4 | Wild > Mutant | - | Highly Conserved | Bumps/repulsions of ligands; Disrupted folding interactions |
D480Y | Wild < Mutant | C3/C4 | Wild < Mutant | Wild-Negative Mutant- Neutral | Highly Conserved | Loss of hydrogen bonds; Perturbed folding |
Y521C | Wild < Mutant | C3/C4 | Wild > Mutant | - | Highly Conserved | Bumps/repulsions of ligands; Disrupted folding interactions; Loss of hydrogen bonds |
R597H | - | C3/C4 | Wild > Mutant | Wild- Positive Mutant-Neutral | Highly Conserved | Loss of ionic interactions; Disrupted folding |
F643L | - | C-Tail | Wild > Mutant | - | Highly Conserved | Loss of hydrophobic interactions; Disrupted folding |