Fig. 3

Identification of modules associated with CD8 + T cells in the UCEC cohort. A Topological analysis of soft threshold parameters. The optimal soft threshold was determined to be 18 by assessing the fitting index and average connectivity. B Cluster dendrogram of module eigengenes. 19 gene modules were clustered and modules with high similarity were combined, resulting in the identification of 10 distinct modules. C Heatmap illustrating the correlation between the 10 gene modules and 21 types of immune infiltrating cells. The numbers in each square represent the Pearson correlation coefficients, with red indicating a positive correlation, blue indicating a negative correlation, and the darkness of the color representing the strength of the correlation. The magenta module showed the highest positive correlation with CD8⁺T cells. D Cluster dendrogram of the 10 gene modules based on 56719 gene expression profiles in the TCGA-UCEC cohort