Fig. 4

Construction of subgroups based on CD8⁺T cells and exploration of survival and immune characteristics. A Non-negative matrix factorization (NMF) was employed to partition the TCGA-UCEC cohort samples into two distinct subtypes, C1 and C2 (k = 2). B, C Dimensionality reduction using PCA and tSNE algorithms revealed significant dispartities in CD8⁺T cell-based gene expression profiles between the two subtypes D K-M survival curves of UCEC patients with CD8⁺T cell molecular subtypes in the two groups demonstrated a noteworthy increase in OS among patients belonging to group C2 compared to shoes in group C1. E Comparison of the stromal score, immune score and ESTIMATE score between patients in the C1 and C2 subgroups. F, G Box plots on CIBERSORT and ssGSEA algorithms illustrated immune infiltration landscapes in the TIME of patients in C1 and C2 groups, in which the infiltration level of CD8.⁺T cells showed significant differences between the two algorithms. ns: no significant statistical difference, *P < 0.05, **P < 0.01, ***P < 0.001