Fig. 7

Correlation analyses between NIRS and immune cell infiltration. A, B Box plots based on CIBERSORT and ssGSEA algorithms depicted the infiltration landscape of 22 and 23 immune cells in the TIME of patients with high- and low- NIRS, and the infiltration levels of CD8⁺ T cells showed significant differences in both algorithms. C, D The correlation matrix between NIRS and 22 and 23 kinds of immune cell infiltration levels were obtained based on CIBERSORT and ssGSEA algorithms. Red represented positive correlation, blue represented negative correlation, in which CD8⁺ T cells showed the strongest negative correlation with NIRS in both algorithms. E The differences of the stromal, immune and ESTIMATE scores between high- and low- NIRS groups. F–H Correlation analyses of characteristic genes CTSW (F), CD3D (G) and CD48 (H) with CD8⁺T cell infiltration levels assessed by CIBERSORT and ssGSEA algorithms. ns no significant difference, *P < 0.05, **P < 0.01, ***P < 0.001