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Fig. 1 | Cancer Cell International

Fig. 1

From: Free-fatty acid receptor-1 (FFA1/GPR40) promotes papillary RCC proliferation and tumor growth via Src/PI3K/AKT/NF-κB but suppresses migration by inhibition of EGFR, ERK1/2, STAT3 and EMT

Fig. 1

FFA1 expression is increased in pRCC and visibly lost in ccRCC. Expression of FFA1 was determined in normal (noncancerous) tissue compared with adjacent patient-matched type 1 pRCC in stage T1a (A), type 1 pRCC in stage T3a (B), ccRCC in stage T1a (C), and ccRCC in stage T4 (D). For each, representative images were captured using an Echo Revolve microscope with the left image (numbered) representing the 20× magnification field and the right image representing 170% zoom to the center of the field. Panels 1–2 correspond to the negative control condition, which lacks the FFA1 antibody. Panels 3–4 represent specific staining in the presence of the FFA1 antibody. A Expression of FFA1 is visibly higher in stage T1a pRCC (A4) compared to patient-matched adjacent normal tissue (A3). B Expression of FFA1 is visibly higher in stage T3a pRCC (B4) compared to patient-matched normal tissue (B3). Importantly, the expression of FFA1 is increased in stage T3a (B4) compared to stage T1a (A4). C Expression of FFA1 is visibly lower in stage T1a ccRCC (C4) compared to patient-matched adjacent normal tissue (C3). D Expression of FFA1 is visibly absent in stage T4 ccRCC (D4) compared to patient-matched normal tissue (D3)

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Cancer Cell International

ISSN: 1475-2867

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