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Fig. 4 | Cancer Cell International

Fig. 4

From: Free-fatty acid receptor-1 (FFA1/GPR40) promotes papillary RCC proliferation and tumor growth via Src/PI3K/AKT/NF-κB but suppresses migration by inhibition of EGFR, ERK1/2, STAT3 and EMT

Fig. 4

FFA1-mediated pRCC cell proliferation is regulated by PI3K/AKT and c-Src. A FFA1 agonism increased the expression of PI3K compared to the vehicle-treated control. The graphical results shown are representative of 5 independent experiments quantifying the p85α-PI3K subunit. B FFA1 agonism increased the phosphorylation of AKT at Ser473 compared to vehicle-treated control. The graphical results shown are representative of 5 independent experiments quantifying the phosphorylation of AKT at Ser473. C FFA1 agonism increased the expression of phosphorylated Src (Tyr416) compared to vehicle-treated control. The graphical results shown are representative of three independent experiments quantifying the phosphorylation of Src at Tyr416

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Cancer Cell International

ISSN: 1475-2867

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