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Fig. 8 | Cancer Cell International

Fig. 8

From: Free-fatty acid receptor-1 (FFA1/GPR40) promotes papillary RCC proliferation and tumor growth via Src/PI3K/AKT/NF-κB but suppresses migration by inhibition of EGFR, ERK1/2, STAT3 and EMT

Fig. 8

FFA1 agonism modulates regulators of EMT. A FFA1 agonism inhibits the expression of E-cadherin, vimentin, and FN1 compared to vehicle-treated control. The graphical results shown are representative of four independent experiments quantifying the respective protein. Statistical significance was determined by paired t-test. * denotes p < 0.05 and ** denotes p < 0.01 versus the control condition. C Downregulation of β-arrestin results in increased expression of FN1 whereas upregulation of β-arrestin-2 decreases FN1 expression. FFA1 agonism exhibited strong activation of FN1 when β-arrestin-2 was overexpressed and minimal activation when β-arrestin was downregulated. The results shown are representative of three independent experiments

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Cancer Cell International

ISSN: 1475-2867

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