Fig. 8
From: CircGNB1 facilitates the malignant phenotype of GSCs by regulating miR-515-5p/miR-582-3p-XPR1 axis
CircGNB1 promoted GSCs tumorigenesis in vivo. a Hematoxylin and eosin staining of intracranial tumor plantation showed the tumor size in the coronal location of five groups. Scale bar = 10 mm. b The measured tumor volumes among each group are indicated. c Representative immunohistochemical staining showed the changes in XPR1, Ki-67, IL6, and IGF2BP3 in each orthotopic xenograft model. Scale bar = 50 µm. d Kaplan–Meier survival curves revealed nude mice’s survival times in each group (n = 10). e Schematic diagram demonstrated that IGF2BP3/circGNB1/miR-515-5p/miR-582-3p/XPR1 promoted malignant phenotype of GSCs via IL6/JAK2/STAT3 axis. Data represent mean ± SD (three independent experiments). *p < 0.05; **p < 0.01; ***p < 0.001