CircGNB1 facilitates the malignant phenotype of GSCs by regulating miR-515-5p/miR-582-3p-XPR1 axis

Table 1 Relationship of circGNB1 expression to clinical features of glioma patients

Clinical features	Samples (n = 70)	CircGNB1 expression^a		P-value
Clinical features	Samples (n = 70)	Low (n = 35)	High (n = 35)	P-value
Sex
Male	34	16	18	P = 0.773
Female	36	19	17
Age
≤ 50	26	12	14	P = 0.251
> 50	44	23	21
WHO grade
II	20	14	6	P < 0.001
III	25	17	8
IV	25	4	21
IDH status
Wild	34	8	26	P = 0.002
Mutant	36	27	9
1p/19q status
Codeletion	37	26	11	P = 0.013
Non-codeletion	33	9	24
H3F3A status
Wild	38	24	14	P = 0.045
Mutant	32	11	21
MGMT status
Methylation	41	29	12	P = 0.018
Unmethylation	29	6	23

^aCircGNB1 expression was detected by qRT-PCR and ranked from low to high. The high expression of circGNB1 was defined as the expression level higher than the median expression level of circGNB1

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