Fig. 3
From: The emerging role of MicroRNA-182 in tumorigenesis; a promising therapeutic target
The involvement of miR-182 in the regulation of signaling pathways in colorectal cancer. (A) FOXO3a with function of inducing the pathway leading to apoptosis and regulating the cell cycle, is suppressed by miR-182 in colorectal cancer. However, lncRNA GAS5 plays a tumor suppressor role with sponging of miR-182. (B) DAB2IP tumor suppressor, which inhibits P13K/AKT/mTOR pathway, is suppressed by the oncogenic functioning of miR-182, leading to CRC cell proliferation