Table 1 The functions and targets of miR-182 in various human cancers
From: The emerging role of MicroRNA-182 in tumorigenesis; a promising therapeutic target
Cancer | Expression | Target Gene | Function | Pathway | Reference |
|---|---|---|---|---|---|
Gsatric cancer | Upregulation Downregulation Downregulation Downregulation Downregulation Downregulation Downregulation | RAB27A CREB1 ANUBL1 UCA1/TIMP2 HOXA9/RUNX3 circFN1 circ-SFMBT2/ CREB1 | Increased Invasion, Migration and Proliferation Decreased cell proliferation Decreased Colony formation and Proliferation Decreased Invasion and Migration Decreased Proliferation and Invasion, Migration Induction of apoptosis Decreased Proliferation and induction of apoptosis | PI3K/Akt/GSK3β, NF-κB | 33 32 39 40 44 50 51 |
Hepatocellular carcinoma | Upregulation Upregulation Upregulation Upregulation Upregulation Upregulation | MTSS1 FOXO3a FOXO1 PDCD4 Ephrin5A RASA1 | Increased metastasis Increased proliferation Increased proliferation Tumorigenesis Increased proliferation Angiogenesis | Wnt/B-catenin | 56 55 58 59 60 61 |
Colorectal cancer | Upregulation Upregulation Upregulation Upregulation Upregulation Downregulation Upregulation | Lnc-AGER-1, AGER lncRNA GAS5, GAS5, FOXO3a SATB2 DAB2IP FoxF2 MTDH ST6GALNAC2 | Increased Proliferation and Migration Increased Proliferation Increased metastasis Increased Proliferation, Invasion and Angiogenesis Invasion, Proliferation and Metastasis Decreased Proliferation, Invasion and Metastasis Increased Drug resistance, Proliferation, Colony formation | NF-κB and Erk1/2, PI3K /Akt Wnt/β-catenin, PI3K/Akt/mTOR Wnt/β-catenin PI3K/Akt | 71 72 75 77 79 80 82 |
Prostate cancer | Upregulation Upregulation Upregulation Upregulation | FOXO1 RECK FOXF2 PHD, FIH | Increased invasion, migration and proliferation Increased invasion Increased invasion Angiogenesis | RECK/MMP2 Wnt | 84 85 85 87 |
Cervical cancer | Downregulation Upregulation | DNMT3a FBXW7 | Hypermethylation of tumor suppressor genes Increased invasion and cell proliferation | Â | 88 91 |
Osteocarcinoma | Downregulation Downregulation Downregulation | HOXA9 TIAM1 EBF2 | Decreased cell proliferation and induction of apoptosis Decreased cell proliferation, metastasis and migration Decreased invasion and migration | Wnt/B-catenin | 92 93 94 |
Breast cancer | Upregulation Upregulation Upregulation Upregulation Upregulation Upregulation Upregulation | BRCA1, BRCA2 RECK circRNA_000554, ZFP36 CASP9 FOXO1 FOXF2 PTEN | Increased Resistance to PARP1 Increased Invasion, Colony formation Increased Migration, Invasion and Proliferation Increased Survival, proliferation Increased Proliferation and Colony formation Increased Metastasis Increased Proliferation and invasion | Wnt/β-catenin TGFβ/Vimentin/ N-cad/E-cad/Snail1/ Twist1 | 102 104 95 106 108 109, 110 112 |
Glioma | Upregulation Upregulation | FBXW7 PCDH8 | Increased cell proliferation and migration Increased invasion and migration | JAK/STAT3 | 116 119 |
Pancreatic cancer | Upregulation | β-TrCP2 | Tumor progression | β-catenin / TCF | 121 |
Melanoma | Upregulation | MITF-M | Increased cell proliferation and migration | Â | 123 |
Lung cancer | Upregulation Upregulation Upregulation Downregulation Downregulation Upregulation Upregulation | FBXW11, FBXW7 PDCD4 FOXO3 RGS17 Cortactin LINC00173, AGER Sp1, FOXO3 | Increased cell growth and Colony formation Increased Proliferation, metastasis and invasion Decreased Radiosensitizing Decreased Colony formation, Proliferation and cell Growth Decreased Metastasis Increased Proliferation and Migration Increased Invasion and Migration | Cdc42/N-WASP NF-κB N-cadherin, ADAM9 | 23 127, 129 130 125 132 126 133 |
Esophageal squamous | Upregulation | YWHAG | Increased cell proliferation and metastasis | Â | 134 |
Renal cell carcinoma | Downregulation Downregulation Downregulation | FLOT1 IGF1R mTOR | Decreased cell proliferation Mediated migration and cell proliferation Decreased cell proliferation and invasion | Akt/FOXO3a P13k/Akt/mTOR | 135 136 137 |