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Fig. 5 | Cancer Cell International

Fig. 5

From: Methylmalonic acid promotes colorectal cancer progression via activation of Wnt/β-catenin pathway mediated epithelial–mesenchymal transition

Fig. 5

MMA promotes tumor growth in vivo. A The images of primary tumor samples obtained from mice subcutaneously injected with HCT116 cells treated with MMA and control cell groups. B, C The relative tumor volumes (B) and weights (C) at the endpoint were analyzed (n = 5). D, E Western blot analysis of the tumor samples of EMT-related proteins showed that epithelial markers were downregulated and mesenchymal markers were upregulated in the MMA-induced group. F, G Western blot analysis of the tumor samples of Wnt/β-catenin signaling-related proteins showed that the expression of β-catenin increased while p-GSK-3β (Ser9) decreased in the MMA-induced group. (*P < 0.05, **P < 0.01, ***P < 0.001)

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Cancer Cell International

ISSN: 1475-2867

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