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Fig. 6 | Cancer Cell International

Fig. 6

From: Exosome-derived circKIF20B suppresses gefitinib resistance and cell proliferation in non-small cell lung cancer

Fig. 6

CircKIF20B regulated mitochondrial function and OXPHOS by MEF2A in NSCLC. A GSEA analysis found that the expression of MEF2A was significantly negatively correlated with mitochondrial function and OXPHOS. B ATP assay of circKIF20B-KD cells and circKIF20B-OE cells. C Mitochondrial membrane potential assay of circKIF20B-KD cells and circKIF20B-OE cells by TMRE. CCCP is a positive control. D and E The OCR analysis of PC9GR cells co-transfected with LV3-NC and pEX3-NC, circKIF20B-KD cells transfected with pEX3-NC, and circKIF20B-KD cells transfected with pEX3-MEF2A via Seahorse. F and G The OCR analysis of PC9GR cells co-transfected with GV689-NC and siRNA-NC, circKIF20B-OE cells transfected with siRNA-NC, and circKIF20B-OE cells transfected with siRNA1-MEF2A via Seahorse

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Cancer Cell International

ISSN: 1475-2867

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