Fig. 1

Serum exosomal hsa_circ_000200 acts as a potential biomarker for GC diagnosis. A Schematic diagram of the formation of hsa_circ_000200. B The level of hsa_circ_000200 under RNase R treatment compared with the level of β-actin. C The sequencing results of hsa_circ_000200. D The expression of hsa_circ_000200 in 98 paired of GC tissues and paracancer tissues. E Survival analysis of GC patients according to the expression of hsa_circ_000200 in tissues. F The area under the ROC curve of the GC tissues (Sensitivity = 82.65%, Specificity = 40.82%). G The expression of hsa_circ_000200 in 54 paired of GC patient serum. H The area under the ROC curve of the GC patient serum (Sensitivity = 50%, Specificity = 81.48%). I The expression of hsa_circ_000200 in 50 paired of GC patient serum-derived exosomes. J The area under the ROC curve of the GC patient serum-derived exosomes (Sensitivity = 98%, Specificity = 44%). *P < 0.05, **P < 0.01, ***P < 0.001