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Fig. 3 | Cancer Cell International

Fig. 3

From: Exosomal hsa_circ_000200 as a potential biomarker and metastasis enhancer of gastric cancer via miR-4659a/b-3p/HBEGF axis

Fig. 3

Hsa_circ_000200 promotes the progression of GC and maintains its stemness. A Hsa_circ_000200 knockdown efficiency is assessed by qRT-PCR. B Assessment of the proliferation in MKN-45 and HGC-27 cells transfected with control or hsa_circ_000200 ASO by CCK8 assay. C The number of cell clones after hsa_circ_000200 knockdown in MKN-45 and HGC-27 cells. D Hsa_circ_000200 knockdown inhibits the migration of MKN-45 and HGC-27 cells. E Hsa_circ_000200 knockdown inhibits the invasion of MKN-45 and HGC-27 cells. F The expression of proliferation, metastasis, and stemness-related proteins in GC cells after hsa_circ_000200 knockdown. G Hsa_circ_000200 overexpression efficiency is assessed by qRT-PCR. H Assessment of the proliferation in AGS cells transfected with control or hsa_circ_000200 plasmid by CCK8 assay. I. The number of cell clones after hsa_circ_000200 overexpression in AGS cells. J Hsa_circ_000200 overexpression promotes the migration and invasion of AGS cells. K The expression of proliferation, metastasis, and stemness-related proteins in GC cells after hsa_circ_000200 overexpression. *P < 0.05, **P < 0.01, ***P < 0.001

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Cancer Cell International

ISSN: 1475-2867

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