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Fig. 4 | Cancer Cell International

Fig. 4

From: LncRNA LZTS1-AS1 induces proliferation, metastasis and inhibits autophagy of pancreatic cancer cells through the miR-532 /TWIST1 signaling pathway

Fig. 4

LncRNA LZTS1‐AS1 sponges miR-532 in PANC; A: The binding sequence and interaction site of LZTS1-AS1 and miR-532 predicted by starBase; B: Transfection with miR-532 mimics effectively overexpressed miR-532 in CFPAC-1 cells, **P < 0.01 compared with NC mimics; C: Dual luciferase assay verified the targeting relationship between LZTS1-AS1 and miR-532 in CFPAC-1 cells, **P < 0.01 compared with NC mimics; D: RIP assay showed that LZTS1-AS1 and miR-532 were enriched in the compounds precipitated by anti-AgO2 antibody, **P < 0.01 and ##P < 0.01 compared with IgG; E: Knockdown of LZTS1-AS1 in CFPAC-1 cells significantly increased the expression level of miR-532, **P < 0.01 compared with si-NC; F: The expression of miR-532 was significantly decreased in PANC tissues, **P < 0.01 compared with Non-tumor; G: LZTS1-AS1 was negatively correlated with miR-532 expression in PANC tissues, r2 = 0.8349

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