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Fig. 8 | Cancer Cell International

Fig. 8

From: LncRNA LZTS1-AS1 induces proliferation, metastasis and inhibits autophagy of pancreatic cancer cells through the miR-532 /TWIST1 signaling pathway

Fig. 8

MiR-532 inhibits the proliferation and tumorigenesis of PANC cells by negatively regulating TWIST1; A: Transfection of miR-532 mimics significantly reduced the expression level of TWIST mRNA, and TWIST1 plasmid transfection effectively overexpressed TWIST1 mRNA; B: Transfection of miR-532 mimics significantly reduced the expression level of TWIST protein, and TWIST1 plasmid transfection effectively overexpressed TWIST1 protein; C: Overexpression of TWIST1 reversed the miR-532-inhibited cell proliferation; D: Overexpression of TWIST1 reversed the miR-532-inhibited cell colony formation; E: Overexpression of TWIST1 reversed the miR-532-inhibited expression of Cyclin D1 and MMP-9; F: Overexpression of TWIST1 reversed the miR-532-inhibited cell oncogenicity; *P < 0.05 and **P < 0.01 compared with NC mimics + pcDNA3.1, ##P < 0.01 compared with miR-532 mimics + pcDNA3.1

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Cancer Cell International

ISSN: 1475-2867

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