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Fig. 1 | Cancer Cell International

Fig. 1

From: Tumor-derived small extracellular vesicles promote breast cancer progression by upregulating PD-L1 expression in macrophages

Fig. 1

Alteration of the immunity of TAMs in BC metastasis. (A) The CD68 and CD163 expression levels of TAMs in early BC tissues, advanced BC tissues, and the related para cancerous tissues. (B) The proportion of CD163 + TAMs in early and advanced BC tissues detected by IF staining. (C) Heat map showing the PD-L1 expression between BC cells, immune cells, and stromal cells based on scRNA-seq data from GEO datasets. (D) Heat map showing the PD-L1 expression in different types of immune cells. (E) The distribution of PD-L1 in different cell subsets based on scRNA-seq data from GEO datasets. (F) Co-localization of PD-L1 and CD163 on TAM in BC observed by IF. (G) The correlation between M2 macrophage infiltration and PD-L1 expression analyzed using CIBERSORT-ABS method. (H) The correlation between PD-L1 and CD163 expressions

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Cancer Cell International

ISSN: 1475-2867

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