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Fig. 6 | Cancer Cell International

Fig. 6

From: Tumor-derived small extracellular vesicles promote breast cancer progression by upregulating PD-L1 expression in macrophages

Fig. 6

BC-derived sEV-miR-106b-5p and sEV-miR-18a-5p induce PD-L1 expression in macrophages and regulate their polarization. (A) The expression of the top 10 upregulated miRNAs in the macrophages co-cultured with sEVs from BC cells using a RT-qPCR assay. (B-C) The mRNA and protein levels of PD-L1 transfected with miR-106b-5p, miR-18a-5p, miR-501-5p and miR-362-5p mimics in macrophages. (D) The expression differences of miR-106b-5p and miR-18a-5p between M0 macrophages, normal breast cells and BC cells. (E-F) The expression differences of miR-106b-5p and miR-18a-5p between cells and cell derived sEVs. (G-H) The mRNA and protein levels of PD-L1 co-cultured with high levels miR-106b-5p and/or miR-18a-5p sEV.

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Cancer Cell International

ISSN: 1475-2867

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