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Fig. 6 | Cancer Cell International

Fig. 6

From: Integrative analysis of the ST6GALNAC family identifies GATA2-upregulated ST6GALNAC5 as an adverse prognostic biomarker promoting prostate cancer cell invasion

Fig. 6

ST6GALNAC5 promoted the invasion of PCa cells. A ST6GALNAC5 protein levels in non-malignant BPH-1 and multiple PCa cell lines by Western blotting. B The stable ectopic expression of ST6GALNAC5 in DU145 and C4-2 PCa cells. C Effects of ST6GALNAC5 overexpression on the proliferation of DU145 and C4-2 cells. D, E The representative images (D) and quantification (E) of cell invasion for ST6GALNAC5 overexpressed and control DU145 cells by transwell assay. Scale bar, 100 µm. F, G The representative images (F) and quantification (G) of cell invasion for ST6GALNAC5 overexpressed and control C4-2 cells by transwell assay. Scale bar, 100 µm. H Knockdown ST6GALNAC5 by two siRNAs in 22Rv1 cells. I Effect of ST6GALNAC5 knockdown on the proliferation of 22Rv1 cells. J, K The representative images (J) and quantification (K) of cell invasion for ST6GALNAC5-knockdown and siRNA control (siNC) 22Rv1 cells by transwell assay. Scale bar, 100 µm. *, p < 0.05; **, p < 0.01; ***, p < 0.001; ns, p ≥ 0.05

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Cancer Cell International

ISSN: 1475-2867

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