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Fig. 2 | Cancer Cell International

Fig. 2

From: A novel quinoline derivative, DFIQ, sensitizes NSCLC cells to ferroptosis by promoting oxidative stress accompanied by autophagic dysfunction and mitochondrial damage

Fig. 2

DFIQ/FIs mediated ROS accumulation and promoted ferroptosis. a DCFDA/DHE staining of H1299 cells after erastin/DFIQ treatment. b Flow cytometry analysis of H1299 cells after erastin/DFIQ treatment. c Quantification of b. d and e Western blot analysis of ROS catalytic protein expression after DFIQ and erastin b treatment or RSL3 c treatment. d H1299 viability changes after pretreatment with NAC and DFIQ/FIs. ***p > 0.001 compared to control, ##p > 0.01 #p > 0.05 compared with DFIQ/FIs only groups

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Cancer Cell International

ISSN: 1475-2867

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