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Fig. 3 | Cancer Cell International

Fig. 3

From: A novel quinoline derivative, DFIQ, sensitizes NSCLC cells to ferroptosis by promoting oxidative stress accompanied by autophagic dysfunction and mitochondrial damage

Fig. 3

DFIQ/FI treatment mediated mitochondrial damage and mitophagy dysfunction. a MitoSOX Red/MitoTracker Green staining after DFIQ and erastin treatment. b Western blot analysis of mitochondrial damage proteins and mitochondrial protein expression after 6 h of DFIQ and RSL3 treatment. c Confocal microscopy analysis of H1299 cells stained with LysoTracker Red/MitoTracker Green after 6 h of DFIQ and RSL3 treatment. The scale bar is indicated as 20 μm. d Enlarged image of c. e The colocalization of lysosomes (red) and mitochondria (green) in c was quantified by ImageJ. ***p < 0.001 compared with the control, ##p < 0.01 compared with the 200 nM RSL3 group

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Cancer Cell International

ISSN: 1475-2867

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