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Fig. 4 | Cancer Cell International

Fig. 4

From: A novel quinoline derivative, DFIQ, sensitizes NSCLC cells to ferroptosis by promoting oxidative stress accompanied by autophagic dysfunction and mitochondrial damage

Fig. 4

DFIQ treatment promoted autophagic flux disruption. a Western blot analysis of autophagic protein expression after DFIQ/erastin treatment. b Lipofuscin accumulation assay during DFIQ/erastin treatment. Red arrows indicate the accumulation of lipofuscin. CQ: chloroquine, a positive control to inhibit autophagosome and lysosome fusion. The scale bar indicates 100 μm. c Confocal microscopy analysis of 2 μM DFIQ-treated H1299 cells overexpressing EFGP-LC3B and stained with LysoTracker Red. Red arrows indicate autophagolysosomes. The scale bar indicates 20 μm

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Cancer Cell International

ISSN: 1475-2867

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