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Fig. 6 | Cancer Cell International

Fig. 6

From: A novel quinoline derivative, DFIQ, sensitizes NSCLC cells to ferroptosis by promoting oxidative stress accompanied by autophagic dysfunction and mitochondrial damage

Fig. 6

Illustration of the study results. Ferroptosis plays a vital role in oxidative stress-mediated cell death. When oxidative stress is triggered by FIs, autophagy and mitophagy are activated, ROS are removed, and damaged mitochondria are cleared. After DFIQ treatment, autophagic flux was disrupted. Moreover, mitophagy was also disrupted, promoting damaged mitochondria accumulation, elevating ROS and oxidative stress, and ferroptosis

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Cancer Cell International

ISSN: 1475-2867

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