A novel quinoline derivative, DFIQ, sensitizes NSCLC cells to ferroptosis by promoting oxidative stress accompanied by autophagic dysfunction and mitochondrial damage

Table 1 IC₅₀ of FIs after DFIQ treatment

Cell	FIs	IC₅₀				FC IC₅₀
Cell	FIs	Ctrl	95%CI	DFIQ	95%CI	FC IC₅₀
H1299	Erastin	69.61 μM	69.61 ~ 79.66 μM	25.96 μM	11.51 ~ 58.57 μM	0.37
H1299	RSL3	817.7 nM	556.4 ~ 1365 nM	25.31 nM	18.2 ~ 35.2 nM	0.03
H460	Erastin	7.60 μM	5.327 ~ 11.89 μM	5.93 μM	4.086 ~ 8.596 μM	0.78
H460	RSL3	378.6 nM	294.1 ~ 487.4 nM	184.8 nM	128.5 ~ 265.6 nM	0.49
A549	Erastin	5.48 μM	4.00 ~ 7.532 μM	1.14 μM	0.92 ~ 1.41 μM	0.21
A549	RSL3	2917.0 nM	1869 ~ 4551 nM	650.8 nM	238.9 ~ 1772 nM	0.22

FIs ferroptosis inducers, IC₅₀ half maximal inhibitory concentration, 95% CI 95% confidence intervals, FC fold change. N = 4

ISSN: 1475-2867