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Fig. 4 | Cancer Cell International

Fig. 4

From: Lnc-LRRTM4 promotes proliferation, metastasis and EMT of colorectal cancer through activating LRRTM4 transcription

Fig. 4

Lnc-LRRTM4 enhances LRRTM4 expression to accelerate CRC progression. (A) Image of RNA-FISH staining, lnc-LRRTM4 probes are red, nucleus is blue (1000×). (B) Image showed the nearby gene of lnc-LRRTM4 in the NCBI database. (C) The effects of lnc-LRRTM4 knockdown on LRRTM4 mRNA in HCT116 and SW480 cells and the effects of lnc-LRRTM4 overexpression on LRRTM4 mRNA in LoVo cells. (D) The effects of lnc-LRRTM4 knockdown on LRRTM4 protein in HCT116 and SW480 cells and the effects of lnc-LRRTM4 overexpression on LRRTM4 protein in LoVo cells. (E) The effects of LRRTM4 knockdown on proliferation in HCT116 and SW480 cells and the effects of LRRTM4 overexpression on proliferation in LoVo cells. (F) The effects of LRRTM4 knockdown on migration in HCT116 and SW480 cells and the effects of LRRTM4 overexpression on migration in LoVo cells. (G) Statistical analysis of cell numbers from (F). (H) The effects of LRRTM4 knockdown on invasion in HCT116 and SW480 cells and the effects of LRRTM4 overexpression on invasion in LoVo cells. (I) Statistical analysis of cell numbers from (H). Data are the means ± SD (n = 3 independent experiments), ** p < 0.01, *** p < 0.001

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Cancer Cell International

ISSN: 1475-2867

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