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Fig. 5 | Cancer Cell International

Fig. 5

From: Regulatory role of Chitinase 3-like 1 gene in papillary thyroid carcinoma proved by integration analyses of single-cell sequencing with cohort and experimental validations

Fig. 5

CHI3L1 is associated with tumor invasion and metastasis. (A) CHI3L1 mRNA is highly expressed in a variety of malignant tumors. (B) Correlation analysis of CHI3L1 and activated tumor-associated signaling pathways in different malignant tumors. (C) Expression of CHI3L1 in PTC clinical biopsies with different degrees of malignancy. HC, healthy control; NM, no metastasis (TNM stage T1N0, T2N0); LM, general metastasis (TNM stage T1N1a, T3N1a, T3bN1b, T4aN1b, T4bN1b); OIDM, obvious invasion and distant metastasis (TNM stage T4N1bM1), different lowercase letters indicate significant differences (P < 0.05). (D) Expression of CHI3L1 in normal thyroid tissue as control (a), PTC with general metastasis (b) and PTC with obvious invasion and distant metastasis (c) as analyzed by immunohistochemistry. Scale bar, 50 μm

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Cancer Cell International

ISSN: 1475-2867

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