Fig. 7

Efficacy of ITC-6102RO in the CDX model. (A) Therapeutic efficacy of ITC-6102RO in the JIMT-1 xenograft model. The drugs were intravenously injected at 0.3 mg/kg once, n = 5. B7-H3 expression in tumor tissue was detected using IHC (brown, DAB-stained B7-H3; blue, hematoxylin-stained nuclei; scale bar, 10 μm). (B) Mice bearing JIMT-1 tumors were treated intravenously with a single 10 mg/kg dose of ITC-6102RO. One day after treatment, tumors were harvested, embedded in paraffin, and sectioned. DAB images of immunohistochemically stained cleaved caspase-3, γH2AX, and cyclin E were obtained under a microscope. Scale bar, 10 μm. Data values represent the mean ± standard deviation. ***p < 0.001 versus control