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Table 1 Stiffness of human normal and tumoral tissues

From: Tumor matrix stiffness provides fertile soil for cancer stem cells

Organs

Normal (kPa)

Tumor (kPa)

Methods of measurement

Ref.

Breast

3.25

Low-grade IDC: 10.40

DCIS: 16.38

High-grade IDC: 42.52

–

[6]

Lung

0.5–5

20–30

–

[74]

Livera

–

55 in HCC

75 in CCC

66.5 in metastatic tumor

Transient elastography

[129]

Livera

–

Low degree malignant: 8–15

High degree malignant: 14–18

AFM

[135]

Livera

1.5–5

–

Shear elasticity

[134]

Pancreasa

0.4

1.2

AFM

[41]

Pancreasa

< 15

> 40

Harmonic motion elastography (HME)

[159]

Colorectal

0.9

Primary tumor (PT) stage

T1: 2.8

T2: 3.5

T3: 8.8

T4: 13.8

Venustron system

[181]

Distant metastasis

Present: 13.6

Absent: 7

  1. aThe reported stiffness may vary depending on measurement techniques