Table 3 Anti-stiffness treatment strategies and results
From: Tumor matrix stiffness provides fertile soil for cancer stem cells
Target | Pharmacological Agent | Result | Ref. |
|---|---|---|---|
Collagen | Collagozome | 87% reduction in the size of malignant tumors. Enhanced drug delivery to cancer sites | |
LOX | Losartan | Reduced tumor progression and metastasis. Suppressed lung tumor metastasis | |
α5β1 integrin | Volociximab | In bone metastasis or tumorigenesis models, Volociximab (M200) significantly reduced tumor outgrowth and blunted cancer-associated bone destruction | [211] |
α6β5 integrin | Cilengitide | In a variety of pre-clinical studies, the drug reduced the progression of tumors, which led to its study in clinical trials | [212] |
FAK | Defactinib | Defactinib suppressed tumor growth and metastasis in xenografted animals and enhanced their overall survival | [213] |
YAP/TEAD | VGLL4 | VGLL4 suppresses Human Gastric Cancer Tumor Growth | [217] |
YAP/TEAD | Verteporfin | Suppressed the CSC-associated characteristics of gastric cancer cell line and inhibited tumor growth in a xenograft model | [216] |
YAP | Simvastatin | Simvastatin could inhibit cancer cell proliferation, migration, and invasion and promote apoptosis | [215] |