Fig. 7
From: Downregulation of MAL2 inhibits breast cancer progression through regulating β-catenin/c-Myc axis
Stabilizing the β-catenin rescues the inhibition of migration and invasion caused by MAL2 knockdown. A The wound healing ability of MDA-MB-231 and MCF-7 cells infected with sh-NC and sh-MAL2 was determined by scratch assay after treatment with SKL2001(20 µmol/L). B Transwell migration and invasion assays were used to detect the migration and invasion ability of MDA-MB-231 and MCF-7 cells infected with sh-NC and sh-MAL2 after treatment with SKL2001 for 24 h (20 µmol/L). C Wetern blot was used to detect the expression of EMT-related proteins in MDA-MB-231 and MCF-7 cells infected with sh-NC and sh-MAL2 after 24 h SKL2001 (20 µmol/L) treatment. All data were presented as mean ± standard deviation. *P < 0.05; **P < 0.01; ***P < 0.001; n = 3