Skip to main content

Table 2 Peripheral blood laboratory inflammatory biomarkers

From: Elevated levels of neutrophil related chemokine citrullinated histone H3, interleukin-8 and C-reaction protein in patients with immune checkpoint inhibitor therapy: predictive biomarkers for response to treatment

Inflammatory biomarkers

All patients (85, median/IQR)

non-DCR (47, median/IQR)

DCR (38, median/IQR)

P Value

H3Cit (ng/mL)

11.54(5.76–28.22)

21.27(9.45–65.46)

7.65(2.52–11.29)

P < 0.001

IL-8 (pg/mL)

118.64(48.03-319.98)

289.81(125.94-670.42)

91.02(45.63-181.91)

P < 0.001

IL-18 (pg/mL)

221.38(159.98-382.02)

245.88(191.38–489.00)

210.94(158.53-323.98)

P = 0.258

IL-18BP (pg/mL)

947.59(459.64-1316.98)

766.93(459.64-1294.38)

1100.72(250.78-1797.94)

P = 0.528

WBC (109/L)

6.19(5.32–7.90)

6.47(5.44–8.32)

5.69(4.83–6.95)

P = 0.090

NEU (109/L)

4.04(3.09–5.36)

4.29(3.29–5.57)

3.94(2.91–5.17)

P = 0.356

LYM (109/L)

1.51(1.04–1.79)

1.55(1.06–1.98)

1.41(1.02–1.76)

P = 0.331

MO (109/L)

0.41(0.33–0.55)

0.46(0.36–0.58)

0.38(0.29–0.52)

P = 0.074

EO (109/L)

0.10(0.06–0.17)

0.10(0.06–0.17)

0.10(0.05–0.16)

P = 0.487

BASO (109/L)

0.03(0.02–0.05)

0.03(0.02–0.05)

0.03(0.02–0.05)

P = 0.531

PLT (109/L)

273.00(212.50–318.00)

273.00(201.00-310.00)

279.50(213.25–327.50)

P = 0.714

NLR

2.95(2.19–4.45)

2.92(2.06–4.52)

3.03(2.39–3.87)

P = 0.939

LMR

3.00(2.08–4.64)

2.85(2.00-5.07)

3.17(2.35–4.33)

P = 0.838

PLR

203.29(138.44-256.74)

203.03(115.48-255.14)

205.31(165.10-258.71)

P = 0.466

ALB (g/L)

42.10(39.25-46.00)

41.30(38.00-43.70)

43.95(40.28–46.63)

P = 0.020

GLB (g/L)

30.61(26.19–33.44)

30.94(28.07–35.48)

29.44(25.27–33.07)

P = 0.163

CRP (mg/L)

9.00(1.44–30.34)

17.31(4.09–78.19)

2.58(0.97–10.17)

P < 0.001

SAA (mg/L)

13.99(5.15-102.35)

51.60(8.85-220.95)

7.70(4.15–38.80)

P = 0.001