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Fig. 4 | Cancer Cell International

Fig. 4

From: Knockdown of TFRC suppressed the progression of nasopharyngeal carcinoma by downregulating the PI3K/Akt/mTOR pathway

Fig. 4

Xenograft tumor formation of HK1-EBV cell with knockdown of TFRC in nude mice. (A) There was no difference on mouse body weight. (B) Growth curves showed that knockdown of TFRC significantly decreased tumor volume from day 9 compared that in control mouse. (C) Nude mice were sacrificed 19 days after initial implantation and (D) surgically excised tumor tissues. (E) Average weight of implanted tumors in siTFRC#2-HK1-EBV and siCtrl-HK1-EBV xenograft-bearing mice. (F, G) The xenograft tumors were stained and show that TfR level was significantly downregulated, and the Ki67 staining was significantly decreased in TFRC knockdown group compared with control group, as assessed by IHC. Asterisks indicate **p < 0.01, ***p < 0.001 compared to control

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Cancer Cell International

ISSN: 1475-2867

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